Contraindicated. Coadministration of doravirine with a robust CYP3A inducer may well lessen doravirine plasma concentrations and/or effects. Possible for loss of virologic reaction and doable resistance to doravirine.
After stopping a CYP3A4 inducer, as being the effects on the inducer drop, the fentanyl plasma concentration will maximize which could improve or prolong each the therapeutic and adverse effects.
pentobarbital will reduce the extent or outcome of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will raise the degree or influence of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with powerful CYP3A4 inducers reduced ivosidenib plasma concentrations.
benzhydrocodone/acetaminophen and pentobarbital both equally raise sedation. Stay clear of or Use Alternate Drug. Limit use to clients for whom substitute remedy solutions are inadequate
pentobarbital will minimize the level or result of irinotecan liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Contraindicated (one)pentobarbital will minimize the extent or result of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with solid CYP3A4 inducers can lead to lowered serum concentrations and loss of antimalarial efficacy
pentobarbital decreases levels of amphotericin B deoxycholate by inhibition of GI absorption. Applies only to oral method of both brokers. Minimal/Significance Not known.
To attenuate the potential for overdosage or the event of dependence, limit the prescribing and dispensing of sedative-hypnotic barbiturates, to the amount essential for the interval right until the next appointment
pentobarbital will lessen the extent or influence of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the extent or influence of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the level or result of atorvastatin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. read more Use Warning/Observe.
Too speedy administration may possibly bring about respiratory melancholy, laryngospasm, apnea, or vasodilation with fall in hypertension
If inducer is discontinued, consider oliceridine dosage reduction and check for signs of respiratory despair.